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Venkata Ramana, D.
- Formulation and Evaluation of Immediate Release Tablets of Dasatinib using Croscarmelose Sodium
Abstract Views :156 |
PDF Views:3
Authors
Chinmaya Keshari Sahoo
1,
D. Venkata Ramana
2,
Nalinikanta Sahoo
3,
Kanhu Charan Panda
4,
Uttam Prasad Panigrahy
5
Affiliations
1 Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Hyderabad, Telangana-500014, IN
2 Department of Pharmaceutical Technology, Netaji Institute of Pharmaceutical Sciences, Toopranpet, Yadadri Bhongir, Telangana-508252, IN
3 Department of Pharmaceutical Analysis and Quality Assurance, MNR college of Pharmacy Fasalwadi, Sangareddy, Medak, Telangana, 502294, IN
4 Department of Pharmaceutics, Anwar-ul-Uloom College of Pharmacy, Rangareddy, Telangana, IN
5 Department of Pharmaceutical Analysis and Quality Assurance, Malla Reddy College of Pharmacy, Maisammaguda, Hyderabad, Telangana-500014, IN
1 Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Hyderabad, Telangana-500014, IN
2 Department of Pharmaceutical Technology, Netaji Institute of Pharmaceutical Sciences, Toopranpet, Yadadri Bhongir, Telangana-508252, IN
3 Department of Pharmaceutical Analysis and Quality Assurance, MNR college of Pharmacy Fasalwadi, Sangareddy, Medak, Telangana, 502294, IN
4 Department of Pharmaceutics, Anwar-ul-Uloom College of Pharmacy, Rangareddy, Telangana, IN
5 Department of Pharmaceutical Analysis and Quality Assurance, Malla Reddy College of Pharmacy, Maisammaguda, Hyderabad, Telangana-500014, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 3 (2017), Pagination: 833-838Abstract
The objective of the present study was to develop an immediate release tablet of Dasatinib using different concentrations of cross carmelose sodium (CCS) as superdisintegrant with a view to gain rapid disintegration in gastric pH for treatment of chronic myeloid leukemia (CML) and acute myeloid leukemia (AML).Five different formulations of Dasatinib immediate release tablets were prepared using wet granulation method. Different pre compression and post compression characterization of tablet was carried out. In vitro drug release studies were carried out in USP II paddle type dissolution apparatus for different formulation and the batch containing 5% CCS gave maximum amount of drug release of 99.14%.Drug and excipients compatibility studies were carried out through FTIR spectroscopy. FTIR spectroscopy studies reveled that there is no interaction between drug and different excipients used in formulation. Short term stability studies (at 40±2°C/75±5% RH) on the best formulation indicated that there no significant changes in drug content.Keywords
Immediate Release Tablets, Dasatinib, CCS, in Vitro Drug Release Study, FTIR Spectroscopy.
- Formulation and Evaluation of Immediate Release Tablets of Topiramate using Sodium Starch Glycolate
Abstract Views :209 |
PDF Views:0
Authors
Kanhu Charan Panda
1,
Niranjan Panda
1,
Chinmaya Keshari Sahoo
2,
Jimidi Bhaskar
3,
D. Venkata Ramana
4
Affiliations
1 Department of Pharmaceutics, Anwar-ul-Uloom College of Pharmacy, Hyderabad, Telangana-500001, IN
2 Department of Pharmaceutics, Malla Reddy College of Pharmacy (Affiliated to Osmania University), Maisammaguda, Secunderabad, Telangana-500014, IN
3 Department of Pharmaceutics, KLR Pharmacy College, Paloncha, Bhadradri, Kothagudem, Telangana-507115, IN
4 Department of Pharmaceutical Technology, Samskruti College of Pharmacy, Kondapur, Ghatkesar, Medchal, Telangana, IN
1 Department of Pharmaceutics, Anwar-ul-Uloom College of Pharmacy, Hyderabad, Telangana-500001, IN
2 Department of Pharmaceutics, Malla Reddy College of Pharmacy (Affiliated to Osmania University), Maisammaguda, Secunderabad, Telangana-500014, IN
3 Department of Pharmaceutics, KLR Pharmacy College, Paloncha, Bhadradri, Kothagudem, Telangana-507115, IN
4 Department of Pharmaceutical Technology, Samskruti College of Pharmacy, Kondapur, Ghatkesar, Medchal, Telangana, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 6 (2019), Pagination: 3024-3028Abstract
The aim of the current study was to develop immediate release tablets (IRT) of topiramate using different concentrations of sodium starch glycolate (SSG) as super disintegrant. Four different formulations of IRT were prepared using wet granulation method. Different pre compression and post compression characterization of tablet was carried out. In vitro drug release studies were carried out in USP II paddle type dissolution apparatus for different formulation and the batch containing 7.5 mg of SSG per tablet gave maximum amount of drug release of 90.76% at the end of 50 mins. Drug and excipients compatibility studies were carried out through FTIR spectroscopy. FTIR spectroscopy studies revelled that there is no interaction between drug and different excipients used in formulation. Short term stability studies (at 40±2ºC/75±5% RH) on the best formulation indicated that there were no significant changes in release profile and drug content after a period of one to three month. Among all the formulations, F4 formulation was finally optimized.Keywords
IRT, Topiramate, SSG, Drug Release, FTIR Spectroscopy.References
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